Fig. 6: Binding mode of namodenoson.
From: Structural insights into the agonist selectivity of the adenosine A3 receptor
a Superimposition of adenosine- and namodenoson-bound A3R. b Binding mode of namodenoson. Black dashed lines indicate hydrogen bonds. c Close-up view of the hydrophobic pocket of the namodenoson-bound structure. The 3-iodobenzyl group of namodenoson wedges into the hydrophobic pocket. d Close-up view of the interactions around the chloro group of namodenoson. e Close-up view of the interactions around the N-methylcarboxamide group of namodenoson. f Cross section of the orthosteric pocket of A3R. Namodenoson fills the orthosteric pocket comprehensively.
