Table 2 Validation sets numbers and characteristics for buccal, cervical, and blood DNA methylation data used in validating the developed WID indices
From: Systems epigenetic approach towards non-invasive breast cancer detection
Characteristic | Buccal validation set | Cervical validation set | Blood GSE237036 | |||
|---|---|---|---|---|---|---|
BC n = 94 | CO n = 93 | BC n = 91 | CO n = 93 | BC n = 50 | CO n = 30 | |
Age at sample taken, Mean (SD) | 53 (12) | 54 (12) | 53 (12) | 54 (12) | - | - |
Body mass index, Mean (SD) | 25.2 (6.1) | 26.5 (4.9) | 25.2 (6.1) | 26.5 (4.9) | - | - |
Menopausal status, n (%) | ||||||
Post | 50 (53) | 51 (55) | 49 (54) | 51 (55) | - | - |
Pre | 44 (47) | 42 (45) | 42 (46) | 42 (45) | - | - |
Current smoker, n (%) | ||||||
No | 84 (89) | 83 (89) | 84 (92) | 83 (89) | - | - |
Yes | 7 (7.4) | 9 (9.7) | 7 (7.7) | 9 (9.7) | - | - |
Unknown | 3 (3.2) | 1 (1.1) | - | 1 (1.1) | - | - |
Stage (T), n (%) | ||||||
T1 | 38 (40) | - | 36 (40) | - | - | - |
T2 | 51 (54) | - | 50 (55) | - | - | - |
T3 | 4 (4.3) | - | 4 (4.4) | - | - | - |
Unknown | 1 (1.1) | - | 1 (1.1) | - | - | - |
Stage (N), n (%) | ||||||
N0 | 39 (41) | - | 38 (42) | - | - | - |
N1 | 35 (37) | - | 33 (36) | - | - | - |
N2 | 9 (9.6) | - | 9 (9.9) | - | - | - |
N3 | 8 (8.5) | - | 8 (8.8) | - | - | - |
Unknown | 3 (3.2) | - | 3 (3.3) | - | - | - |
Grade, n (%) | ||||||
Grade I | 2 (2.1) | - | 2 (2.2) | - | - | - |
Grade II | 40 (43) | - | 38 (42) | - | - | - |
Grade III | 51 (54) | - | 50 (55) | - | - | - |
Unknown | 1 (1.1) | - | 1 (1.1) | - | - | - |
ER, n (%) | ||||||
Neg | 12 (13) | - | 12 (13) | - | - | - |
Pos | 81 (86) | - | 78 (86) | - | - | - |
Unknown | 1 (1.1) | - | 1 (1.1) | - | - | - |
PR, n (%) | ||||||
Neg | 23 (24) | - | 23 (25) | - | - | - |
Pos | 68 (72) | - | 65 (71) | - | - | - |
Unknown | 3 (3.2) | - | 3 (3.3) | - | - | - |
