Fig. 3: Comparison in assigning nucleotide types for EM2NA, CryoREAD, ModelAngelo, and Phenix on the test set of n = 50 cryo-EM maps.
From: Automated detection and de novo structure modeling of nucleic acids from cryo-EM maps
a Box plots of sequence matches for the built models. b Box plots of sequence recalls for the built models. The box plots indicate the means (cross), medians (median-line), first and third quartiles (bounds of boxes), and ± 1.0 standard deviations (whiskers). Mean values are marked near the box. c Head-to-head comparison of sequence matches. d Head-to-head comparison of sequence recalls. e, f An example of the built model for the SARS-CoV-2 replication-transcription complex bound to GTP, in a pre-catalytic state. The density map (gray) and PDB structure (blue for protein, green for RNA) are shown in e, f shows the comparison of EM2NA, CryoREAD, ModelAngelo, and Phenix, with nucleotide types (A/G/C/U) labeled in different colors (red/green/blue/yellow) and the protein chains from the PDB model colored in transparent gray. Source data are provided as a Source Data file.
