Fig. 4: Multiple hOGG1 molecules binding to a single dsDNA stretch.
From: Structural basis for human OGG1 processing 8-oxodGuo within nucleosome core particles
a 2D classes depicting particles with multiple hOGG1K249Q molecules binding to a dsDNA molecule in 2:1 and 3:1 ratios. b Selected 2D class averages of particles displaying a distinctive kinking pattern at each hOGG1K249Q binding site on the dsDNA stretch. c Top view of an in-silico model illustrating six hOGG1 molecules bound to a single free 601 DNA stretch in a random distribution. The model was generated utilizing the crystal structure of hOGG1 bound to free dsDNA (PDB: 1ebm) and the 601 DNA sequence through the x3dna webserver. (http://web.x3dna.org/). Gray: DNA, orange: hOGG1.
