Fig. 6: Differential abundance of microbiome-derived gut-brain (GB) modules between ASD children (N = 2139) and controls (N = 1646). | Nature Communications

Fig. 6: Differential abundance of microbiome-derived gut-brain (GB) modules between ASD children (N = 2139) and controls (N = 1646).

From: Large-scale metagenomic analysis of oral microbiomes reveals markers for autism spectrum disorders

Fig. 6

a (left) 19 associated (q < 0.005) GB modules from a linear mixed model of ASD diagnosis in 3,785 salivary microbiome samples, adjusted for sex, age, genetic ancestry, sequencing depth, and alpha-diversity, and blocked by family ID. b reactions related to dopamine degradation in the MetaCyc biogenic amine degradation pathway pathway. c (top) reactions related to GABA degradation to ammonium and butyrate in the MetaCyc GABA degradation pathway; (bottom) ASD-associated species contributing to EC numbers that are in the MetaCyc GABA degradation pathway are reported, with the mean difference in enzyme coverage between ASD and NTs, and the number of ASD samples in which the contribution is observed.

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