Fig. 5: Phage CGs exhibit predictable, class-dependent interactions with conventional antibiotics.
From: A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections
a Exposure matrix for PA14 exposed to combinations of phages and antibiotics simultaneously. Blue areas represent synergy, while red areas represent antagonism. The antibiotic concentrations were below their MIC values (sub-MIC) as detailed in the Supplementary Table 3. CTZ ceftazadime, AZT aztreonam, MER meropenem, GEN gentamicin, TOB tobramycin, AMI amikacin, DOX doxycycline, ERY erythromycin, CIP ciprofloxacin, TMP trimethoprim, COL colistin, and RIF rifampin. Data are shown in the matrix as an average of triplicate independent results. b PCA data for responses to phages and antibiotics. c Effectiveness Ratio (%) of 153 clinical P. aeruginosa isolates treated with the KIM-C1 cocktail (Luz24, OMKO1, and PAML-31-1), AZT treatment alone, or the KIM-C1 cocktail plus aztreonam (KIM-C1 + AZT) grown in planktonic form or as a biofilm. Effectiveness was defined as >60% growth suppression over 30 hours. d Effectiveness Ratio (%) of 153 clinical P. aeruginosa isolates treated with either one of three different phage cocktails (KIM-C1, -C2, and -C3), each containing three or four phages from all four different CGs, or a cocktail plus aztreonam. e Suppression Index for 153 clinical P. aeruginosa isolates treated with the KIM-C1 cocktail, AZT alone, or the KIM-C1 cocktail plus aztreonam (KIM-C1 + AZT) grown in planktonic form or as biofilms. Data are shown in the matrix as an average of triplicate independent results. Source data are provided as a Source Data file.
