Fig. 5: Prior heterologous immunity does not affect the cytokine response to YFV infection. | Nature Communications

Fig. 5: Prior heterologous immunity does not affect the cytokine response to YFV infection.

From: Potential role of heterologous flavivirus immunity in preventing urban transmission of yellow fever virus

Fig. 5: Prior heterologous immunity does not affect the cytokine response to YFV infection.

Log2 fold-change in 23 different cytokines and chemokines measured in sera of FR1565 (ZIKV-exposed, seronegative animal) on days 5 and 9 post-YFV infection and compared with baseline levels (a). Log2 fold-change in IL-1ra (b), MCP-1 (c), sCD40L (d), IL-8 (e), and VEGf (f) at 5 DPI and euthanasia timepoints (14 DPI for all animals, 9 DPI for FR1565). Data shown for 23 animals; groups from left to right divided by dotted line are as followed: Flavivirus-naïve, DENV-2-seronegative, DENV-2 P81407-immune, DENV-2 NGC-immune, ZIKV-seronegative, ZIKV PRVABC59-immune, ZIKV DakAr-immune.

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