Fig. 1: PAPS patients have similar phenotypic B cell features compared to HD. | Nature Communications

Fig. 1: PAPS patients have similar phenotypic B cell features compared to HD.

From: Defective germinal center selection results in persistence of self-reactive B cells from the primary to the secondary repertoire in Primary Antiphospholipid Syndrome

Fig. 1: PAPS patients have similar phenotypic B cell features compared to HD.

A Composite UMAP projection of B cell subsets, generated using 12 parameters analyzed in spectral flow cytometry of PAPS patient and HD samples (n = 30). Composite sample was derived from 5000 representative cells. B Frequencies of B cell subsets from PAPS patients (n = 15) and HD (n = 15). C Composite UMAP projection and frequencies of antigen-experienced B cells. D BCR isotype repartition in patients and HD samples. E Frequencies of aN and rN B cells from patients (n = 15) and HD (n = 15). F Composite UMAP projection and frequencies of DN B cells from patients (n = 15) and HD (n = 15). Significance was determined using a Two-tailed Mann–Whitney test. Data are presented as mean values ±SEM. aN activated naive B cells, DN double negative, HD healthy donor, PAPS primary antiphospholipid syndrome; rN resting naive B cells.

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