Fig. 3: PL-reactive B cells are part of the natural repertoire and persist after the naive B cell stage in triple-positive PAPS. | Nature Communications

Fig. 3: PL-reactive B cells are part of the natural repertoire and persist after the naive B cell stage in triple-positive PAPS.

From: Defective germinal center selection results in persistence of self-reactive B cells from the primary to the secondary repertoire in Primary Antiphospholipid Syndrome

Fig. 3: PL-reactive B cells are part of the natural repertoire and persist after the naive B cell stage in triple-positive PAPS.

A Flowchart of single B cell immortalization and supernatant screening. B Frequency of PL-reactive in each B cell subsets. C IgG subclasses repartition in non-PL and PL-reactive clones. D Kappa/lambda ratio of non-PL and PL-reactive clones in each B cell subsets. aPL antiphospholipid antibody, CL cardiolipin, PL phospholipid.

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