Fig. 1: Schematic diagram of the CHOOSER framework for identifying and functional screening of CRISPR-Cas systems with self-processing pre-crRNA capability.
From: Discovering CRISPR-Cas system with self-processing pre-crRNA capability by foundation models
Spring-like symbols indicate CRISPR arrays, while arrowed rectangles indicate ORFs (Cas9 proteins are colored orange, Cas12 proteins are colored blue, Cas13 proteins are colored green, other proteins are colored gray, suspected Cas proteins are colored salmon, and untyped proteins are uncolored.) In the mini-CRISPR array, diamonds indicate directed repeats (DR), and colored oval squares indicate different spacers. In DNA cleavage testing, colored rectangles denote various PAM motifs. Source data are provided as a Source Data file.
