Fig. 3: Coronary artery occlusion improves cardiac gene expression. | Nature Communications

Fig. 3: Coronary artery occlusion improves cardiac gene expression.

From: AAV delivery strategy with mechanical support for safe and efficacious cardiac gene transfer in swine

Fig. 3: Coronary artery occlusion improves cardiac gene expression.The alternative text for this image may have been generated using AI.

a Different areas of myocardium from LV base, mid, and apex were collected to study gene distribution. Luciferase expression data were normalized to total protein. b, c Luciferase expression in the LV was compared between Continuous (n = 3) and CAO (n = 3) delivery groups (b) and between Continuous delivery without (n = 3) and with (n = 3) the addition of MCS (c) to assess the contribution of balloon occlusions or MCS to gene expression. All n-values represent biological replicates, with each point averaged from technical triplicates within the same animal. Expression is shown as mean ± SEM of biological replicates. Comparisons were conducted as a two-tailed t test with p-value set at 0.05. Source data are provided as a Source Data file. Dotted lines separate linear and logarithmic scales in (b). Infarct refers to the mid-anterior region. Border refers to the infarct-border at the mid-lateral region. Post, posterior; Epi, epicardial; Endo, endocardial; Lat, lateral; Sept, Septum.

Back to article page