Table 1 Chronic cardiac function is not impaired by balloon occlusion delivery

From: AAV delivery strategy with mechanical support for safe and efficacious cardiac gene transfer in swine

  

Continuous

Continuous, MCS

CAO

Stop-flow

Stop-flow, short

p-value [H / η2]

Cardiac output (mL/min)

Pre

5wk

3.36 ± 0.35

4.38 ± 0.27

3.44 ± 0.30

4.16 ± 0.43

3.94 ± 0.23

4.33 ± 0.26

3.50±0.37

3.75±0.09

2.80 ± 0.32

3.51 ± 0.43

0.2420

[5.474 / 0.12]

Heart rate (bpm)

Pre

5wk

68 ± 13

83 ± 6

72 ± 5

72 ± 7

72 ± 2

78 ± 6

75 ± 10

90 ± 22

76 ± 10

72 ± 10

0.6485

[2.478 / − 0.13]

Stroke volume (mL)

Pre

5wk

50.8 ± 4.4

53.0 ± 2.9

47.6 ± 2.1

59.6 ± 8.1

54.6 ± 3.7

55.5 ± 2.3

48.5 ± 5.9

48.1 ± 9.4

37.1 ± 3.0

49.7 ± 6.8

0.6295

[2.585 / − 0.12]

Maximum pressure* (mmHg)

Pre

5wk

105 ± 11

126 ± 5

119 ± 4

128 ± 8 (126 ± 7)

117 ± 8

133 ± 6

114 ± 15

124 ± 4 (113 ± 12)

75.25 ± 0.3

102.8 ± 15 (107 ± 10)

0.6173

[2.990 / − 0.11]

End-diastolic pressure* (mmHg)

Pre

5wk

15 ± 2.0

13 ± 1.9

15 ± 3.2

13 ± 2.3 (13 ± 1.7)

17 ± 4.7

15 ± 4.7

18 ± 2.4

13 ± 0.7 (11 ± 2.3)

12 ± 3.8

16 ± 2.6 (14 ± 2.7)

0.2124

[5.886 / 0.21]

End-diastolic volume (mL)

Pre

5wk

93.9 ± 5.8

103.8 ± 10.6

88.4 ± 3.2

103.7 ± 8.3

81.6 ± 7.1

97.8 ± 3.9

123.9 ± 16.5

123.6 ± 8.2

87.4 ± 11.2

119.6 ± 36.6

0.6225

[2.624 / − 0.11]

End-systolic volume (mL)

Pre

5wk

49.6 ± 3.6

56.3 ± 7.0

46.2 ± 3.7

59.4 ± 5.0

42.8 ± 6.7

53.5 ± 7.8

77.3 ± 12.3

79.3 ± 7.1

50.8 ± 14.2

83.5 ± 35.5

0.5357

[3.134 / − 0.07]

Ejection fraction (%)

Pre

5wk

47.2 ± 0.6

45.9 ± 1.2

47.9 ± 2.7

42.5 ± 3.2

48.1 ± 3.6

44.4 ± 4.8

38.1 ± 3.6

36.0 ± 3.2

44.4 ± 10.5

34.7 ± 7.5

0.5459

[3.072 / − 0.08]

  1. Average differences in hemodynamic and functional measurements between pre-injection (Pre) and 5 weeks post-injection (5wk) of AAV6.Luc were compared between delivery groups (Continuous, n = 3; Continuous, MCS, n = 4; CAO, n = 3; Stop-flow, n = 4; Stop-flow, short, n = 3; statistical comparisons by Kruskal-Wallis test with significance denoted as p < 0.05). Averages within each group are reflected as mean ± SEM, where n represents the number of animals.
  2. *Averages of three animals (one animal each in three delivery groups) in whom pre-injection pressure measurements could not be obtained are omitted and excluded from analysis; mean ± SEM at 5 weeks, including all animals in the group, are shown in parentheses.
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