Fig. 2: Flowchart of Health and Retirement Study participants inclusion.
From: Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression
The effects of brain health events on epigenetic age (Stage 1) are studied in all participants with DNAm data. The effects of epigenetic age on subsequent brain health events (Stage 2) are studied in participants with DNAm and follow-up data, excluding those with a history of prior events. Genetic associations for epigenetic age are conducted in participants with both genetic and DNAm data. Genetic associations for brain health events are conducted in all participants with genetic data.
