Fig. 3: Associations between epigenetic age and brain health events (stroke, dementia, late-life depression).
From: Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression
A. Cross-sectional analysis: percentage of change in epigenetic ages following a brain health event after adjusting for chronological age, sex, race and ethnicity, hypertension, diabetes, smoking, BMI, history of heart attack, coronary artery disease, angina, or congestive heart failure. N = 4018. Data are presented as linear regression coefficients and 95% confidence intervals. Clocks displayed in red belong to the second generation of epigenetic clocks. B Longitudinal analysis: Odds Ratios of brain health events per one standard deviation increase in epigenetic age adjusting for chronological age, sex, and race and ethnicity. The second-generation epigenetic clocks are highlighted in red. N = 2,967. Data are presented as odds ratios and 95% confidence intervals. Clocks displayed in red belong to the second generation of epigenetic clocks. Source data are provided as a Source Data file.
