Table 2 Multivariable regression results: changes in mean epigenetic age following a brain health event and odds ratios of brain health events per one standard deviation increase in mean epigenetic age

From: Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression

 

1st stage

2nd stage

Outcome

Change in mean epigenetic age as a function of prevalent brain health events

Change in mean odds of incident brain health events as a function per 1 standard deviation increase in mean epigenetic age

Statistical model

Linear regression

Logistic regression

Covariates

% change

Beta (SE)

P

Odds Ratios (95% CI)

P

Unadjusted Model 1

42%

0.42 (0.02)

2.42e-71

2.62 (2.10-3.25)

5.48e-18

Multivariable Model 2

8%

0.08 (0.01)

2.06e-08

1.70 (1.16-2.50)

0.007

Multivariable Model 3

4%

0.04 (0.01)

0.002

1.48 (0.99-2.21)

0.057

  1. Model 2: Adjusted for age, sex and race/ethnicity
  2. Model 3: Adjusted for age, sex, race/ethnicity, hypertension, diabetes, smoking, BMI, history of heart attack, coronary artery disease, angina, or congestive heart failure
  3. P values provided are based on two-sided t-tests for the linear regression results and two-sided Wald tests for the logistic regression results.
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