Fig. 1: Framework overview.
From: Leveraging haplotype information in heritability estimation and polygenic prediction
Haplotypes are clustered in windows along a chromosome to produce haplotype cluster assignments in each genomic window (Step 1). The haplotype cluster assignments across the genome are aggregated for each individual and are used to estimate the genome-wide relationship matrix (Step 2). Using the GCTA software, the genome-wide relationship matrix is used for heritability estimation and polygenic prediction (Step 3).
