Fig. 4: iPSYCH2012 subsets results.
From: Leveraging haplotype information in heritability estimation and polygenic prediction
Predictive performance of polygenic risk scores in subsets of the iPSYCH2012 case-cohort. The left plot shows the performance on the subset of individuals with both parents being born in Denmark, while the right plot shows the performance on the subset of individuals with at least one parent born outside Denmark. “PGC” represents the reference-based polygenic risk scores from PGC GWAS summary statistics using PRSice. PGC GWAS summary statistics were not available for REC. In the left plot, MDD: N = 39,856, REC: N = 28,504, and SCZ: N = 24,881, while in the right plot, MDD: N = 5992, REC: N = 4464, and SCZ: N = 4324. Data are represented as \({R}_{N}^{2}\) values and the interval bars span the 2.5% and 97.5% percentiles from non-parametric bootstrapping of 1000 iterations. Source data are provided as a Source Data file.
