Fig. 3: Structural comparison for zGPR4.
From: Cryo-EM structure of an activated GPR4–Gs signaling complex
a, b Superposition of the active zGPR4–Gs structure with its inactive model (AlphaFold). c The two zGPR4 models are further compared with the β2AR (PDB ID: 7BZ2) and A2BR (PDB ID: 7XY7) structures. d Alignment of zGPR4–Gs (current study) with other non-canonical Gs-coupled structures, including GPR174 (PDB ID: 7XV3), EP2 (PDB ID: 7CX2) and CCKAR (PDB ID: 7EZK). Color codes are indicated at the top-left corner. For clarity, only α5 helix is shown in each Gs-coupled structure.
