Fig. 4: Validation of the transcriptomic signatures.
ROC curves with AUC values for the three tested validation subsets: M. pneumoniae (n = 9) vs. viral pneumonias (n = 10) (black line; AUCM-V), M. pneumoniae (n = 9) vs. non-mycoplasma pneumonias including viral and other bacterial pneumonias (n = 32) (violet line; AUCM-VB) and M. pneumoniae vs. non-mycoplasma bacterial pneumonias (n = 22) (red line; AUCM-B) (left panels). Boxplots of the predicted values using each model in the three validation subsets (right panels). Two-sided Wilcoxon P-values are also displayed. The red dashed line represents the optimal cut off. The boxes represent the distribution of scores for M. pneumoniae, viral and bacterial pneumonia samples. They are defined by the upper and lower quartiles (Q1 and Q3), with the median displayed as a bold-colored horizontal line. The whiskers extend to the most extreme data points within 1.5 times the interquartile range (IQR) from the box. Abbreviations as in legend of Fig. 3. VB all non-mycoplasma pneumonias including viral and other bacterial pneumonias, B bacterial, M M. pneumoniae, V viral.
