Fig. 5: The cellular and organismal impact of Nt-acetylation.
From: Illuminating the impact of N-terminal acetylation: from protein to physiology
A Summary of the physiological impact of NATs in A. thaliana57. B NatC prevents age-dependent motility loss in D. melanogaster. NatC KO fruit flies exhibit muscle developmental defects and motility loss, and these phenotypes are rescued upon UbcE2M overexpression39. C In yeast, NatD-mediated Nt-acetylation (Ac) of histone H4 normally antagonises the methylation (Me) of H4 Arg3, which regulates yeast lifespan. Under calorie restriction, yeast NatD and Nt-acetylation of histone H4 are downregulated, resulting in increased levels of H4 Arg3 methylation and induction of stress response genes such as PNC1, which promotes yeast longevity128. D Post-translational Nt-acetylation of actin mediated by NAA80 in human cells affects cytoskeletal dynamics. Human NAA80 KO cells lacking Nt-acetylation of actin display more cell protrusions and increased cell motility, implicating NAA80 as a cell migration regulator11. KD knockdown, KO knockout.
