Fig. 7: A working hypothesis model for the suppression of RNA silencing by HC-ProTu. | Nature Communications

Fig. 7: A working hypothesis model for the suppression of RNA silencing by HC-ProTu.

From: HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1

Fig. 7: A working hypothesis model for the suppression of RNA silencing by HC-ProTu.The alternative text for this image may have been generated using AI.

a The inside of the H-body for HC-Pro interacts with RNA silencing components. b The working hypothesis for HC-ProTu-induced degradation of AGO1 suggests that HC-ProTu exhibits a heightened inhibitory effect on HEN1 methylation activity. This inhibition results in the incorporation of unmethylated miRNAs (unMet-miRNAs) into AGO1 complexes, which subsequently activate autophagy pathways, leading to the degradation of AGO1.

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