Fig. 6: Differential protein expression profiles in Neo-EVs, AR-Neo-EVs, and Adu-EVs.
From: Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles
a Venn diagram showing the overlap of proteins of differentially expressed Adu-EVs, Neo-EVs, and AR-Neo-EVs. b Gene ontology (GO) analyses of proteins in Adu-EVs, Neo-EVs, and AR-Neo-EVs. c Volcano plot for a comparison of protein expression profiles between different tissue EVs. The x-axis indicates the differential expression profiles, plotting the log2(Fold Change). The y-axis indicates the statistical significance of differences. d Fuzzy c-means clustering analyses of the protein expression profiles of different cardiac tissue EVs. e GO analyses of proteins in cluster 5. f Heatmap of differentially expressed proteins enriched in cluster 5. g Venn diagram showing the overlap of proteins of differentially expressed in cluster 5. h Quantitative analysis of the Ki67 and EdU proliferation assay in cardiomyocytes (n = 6 independent experiments). ***p < 0.001 vs. si-NC. Two-tailed Student’s t-test was used to compare the differences between the two experimental groups. Error bars represent mean ± SEM. Source data are provided as a Source Data file. Exact p values are provided in the Source Data file.
