Fig. 2: Reaction optimization.
From: Asymmetric multi-component trifunctionalization reactions with α-Halo Rh-carbenes
The reactions were conducted on a 0.1 mmol scale: To the mixture of corresponding catalyst (2.0 mol%), CPA 4 (5.0 mol%), 2a (0.30 mmol), 3a (0.10 mmol), and 4 Å MS (150 mg) in CH2Cl2 (1.5 mL) was added a solution of diazo compound 1 in cold CH2Cl2 (1.5 mL) via a syringe pump in 0.5 h under a nitrogen atmosphere at 0 °C; The yields were given as isolated yields, and the ee values were determined by chiral HPLC analysis; N.D. = not detected; *The reaction concentration was diluted to 0.011 mol/L; **15.0 mol% CPA (S)-4d was used.
