Fig. 1: Enrollment Flow Chart.

Flowchart of N = 15 participants who enrolled in the trial and completed a biopsy for CALEC. For simplicity of presentation of results, two additional participants who enrolled in the study are not counted in these 15: One participant in the open enrollment phase discontinued the study before proceeding to biopsy. One participant enrolled in the randomized CLAU group and completed the study through 18 months; this was the only CLAU participant prior to discontinuation of the randomized CLAU arm of the study.