Fig. 2: Schematic Representations of Dystrophin Interactions in the Nervous System.

A Dp427 and Postsynaptic Complexes in Central Inhibitory Synapses. This diagram illustrates the Dp427-associated complex, including α and β dystroglycans, and its role in postsynaptic scaffolding (the black U-shape form represents dystrobrevin). The interaction with key proteins such as Neuroligin-2 (NLGN2), neurexin, S-SCAM, and IQsec3, which are crucial for GABAAR clustering, is depicted. The GABAAR subunits are colour-coded to identify α subunits in light blue, β subunits in purple, and γ2 subunits in red²⁴. B Dp140 complexes in Synapses. This illustration shows the Dp140 complex associated with Ca_v2.1 and glutamate axis. C Dp71 and its Association with AQP4 and Kir4.1 Channels in Astrocyte Endfeet. This panel demonstrates the interaction of Dp71 with AQP4 and Kir4.1 channels within the perivascular astrocyte endfeet, indicating its potential role in neurovascular coupling¹⁰². α-DG α-dystroglycan, β-DG β-dystroglycan, nNOS neuronal nitric oxide synthase, NLGN2 neuroligin 2, IQsec3 gephyrin-associated IQ motif and SEC7 domain-containing protein 3 (also called SynArfGEF), S-SCAM synaptic scaffolding molecule (also called MAGI-2 for membrane-associated guanylate kinase inverted 2); Ca_V2.1 calcium channels Kir: potassium channels, AQP-4 aquaporin-4, α-Dbv-1 α-dystrobrevin-1, DG dystroglycan, Syn syntrophin. Created in BioRender¹⁰³.