Fig. 3: INO-3107 significantly enriches antiviral immune status in airways of responders (n = 12). | Nature Communications

Fig. 3: INO-3107 significantly enriches antiviral immune status in airways of responders (n = 12).

From: DNA immunotherapy for recurrent respiratory papillomatosis (RRP): phase 1/2 study assessing efficacy, safety, and immunogenicity of INO-3107

Fig. 3: INO-3107 significantly enriches antiviral immune status in airways of responders (n = 12).

A Gene set enrichment analysis (GSEA) results for hallmark interferon gamma, interferon alpha, and inflammatory signatures comparing pretreatment papilloma tissue with end of study tissue, inclusive of p value and q value, as determined by one-sided false discovery rate (FDR) correction for multiple comparisons, shown in the inset table. Core enriched genes are displayed with an intensity of color-coding tracking to rank metric scores of those genes. Non-core enriched genes are found in the supplement. B Heatmap of 280 differentially expressed genes (DEGs) in responders using one minus Spearman rank correlation with average linkage for hierarchical clustering and samples grouped by study visit; this gene set was analyzed using ingenuity pathway analysis (IPA), which confirmed the activation of interferon-gamma and interferon alpha signaling pathways in responder tissue at end of study versus screening via p value and z-score, as determined using one-sided Fisher’s exact test and reported in the inset table. HPV human papillomavirus, TMM trimmed mean of M-values, CPM counts per million.

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