Fig. 6: INO-3107 drives significant T-cell infiltration into papillomas.

A Regression analysis for TCRβ sequencing of tissue-localized T-cells in papilloma tissue from screening (pretreatment, left panel) and end of study (right panel) assessed against percent (%) change in surgical frequency during the study year (post-) relative to the year prior (pre-) to study start. Data were displayed as total TCRβ clone counts as determined by summed total reads from n = 17 patients, each represented by an open black diamond. p values and r values are determined by two-sided Spearman correlation analysis. B Left panel: Direct comparison of total TCRβ clone reads in papilloma tissue from Screening (pretreatment) and end of study from n = 17 patients, each represented by an open black diamond. Right panel: TCRβ clone reads in papilloma tissue from Screening (pretreatment) and end of study additionally broken out by clinical outcome where n = 5 non-responders (open red circles) and n = 12 Responders (open green squares). Box and whiskers extend from 25th–75th percentile and minima to maxima, respectively; line at median, + at mean. p values are determined by a two-sided Wilcoxon signed-rank test. Only significant p values are displayed. C Regression analysis of change (Δ) in TCRβ clone reads above Screening (pretreatment) to end of study against change in surgical frequency (%) on the study (post-) as compared to the year prior (pre-) to study start. p value and r value are determined by a two-sided Spearman correlation analysis of n = 17 patients, each represented by an open black diamond. TCRβ T-cell receptor beta chain, Tx treatment.