Fig. 8: Illustration showing the expression pattern and role of EPCR during RNV. | Nature Communications

Fig. 8: Illustration showing the expression pattern and role of EPCR during RNV.

From: Endothelial protein C receptor promotes retinal neovascularization through heme catabolism

Fig. 8: Illustration showing the expression pattern and role of EPCR during RNV.

a EPCR is specifically upregulated in retinal endothelial cells during RNV, and endothelial deletion of Epcr ameliorates RNV. b EPCR regulates the expression of HO-1 and heme catabolism-derived CO through AKT/NRF2/KEAP1 signaling. EPCR blockade decreases CO levels and inhibits retinal angiogenesis. Created in BioRender. Song, H. (2025) https://BioRender.com/r06f399.

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