Fig. 3: Single-cell RNA-seq revealed transcriptome heterogeneity of PitNETs. | Nature Communications

Fig. 3: Single-cell RNA-seq revealed transcriptome heterogeneity of PitNETs.

From: Splicing diversity enhances the molecular classification of pituitary neuroendocrine tumors

Fig. 3: Single-cell RNA-seq revealed transcriptome heterogeneity of PitNETs.The alternative text for this image may have been generated using AI.

a UMAP plots show the 13 single-cell clusters of 195,720 cells from 16 samples. Dots: single cells. Cell type is color-coded. b Scatter plots showing the expression of known subtype markers, including key TFs and hormone genes. Light to dark colors indicate increasing expression levels. c Differential gene expression analysis shows upregulated (in red) and downregulated (in blue) genes from each single-cell cluster. d Functional annotation enrichment analysis of differentially spliced genes in each subtype. The enrichment fold changes are displayed for each term. Source data are provided as a Source Data file.

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