Table 2 Summary of treatment-related adverse events of all grades observed in ≥10% of patients. Data are presented as number (%)

From: Olaparib combined to metronomic cyclophosphamide and metformin in women with recurrent advanced/metastatic endometrial cancer: the ENDOLA phase I/II trial

Adverse events observed > 10% patients

All patients (n = 31)

Grade 1–2

Grade ≥3

Anemia

17(54.8)

5 (16.1)

Fatigue

15(48.4)

4 (12.9)

Nausea

17 (54.8)

0 (0)

Lymphocytopenia

2 (6.5)

10 (32.3)

Diarrhea

10 (32.3)

0 (0)

Neutropenia

5 (16.1)

5 (16.1)

Thrombocytopenia

7 (22.6)

2 (6.5)

Decreased appetite

9 (29.0)

0 (0)

Blood creatinine increased

8 (25.8)

0 (0)

Vomiting

6 (19.4)

0 (0)

Dysgueusia

4 (12.9)

1 (3.2)

Vertigo

4 (12.9)

0 (0)

Dyspepsia/Gastro-esophageal disease

3 (9.7)

1 (3.2)

Dose reduction

18 (58.0)