Fig. 4: Preparation of the chiral amine fragment and total synthesis of lycoposerramine W through late-stage nitrogen deletion. | Nature Communications

Fig. 4: Preparation of the chiral amine fragment and total synthesis of lycoposerramine W through late-stage nitrogen deletion.

From: Enantioselective total synthesis of lycoposerramine congeners through late-stage nitrogen deletion

Fig. 4

A First-generation synthesis of chiral amine fragment 23 from ( ± )− 16. B Second-generation synthesis of chiral amine fragment 23 from (R)-pulegone. C N-deletion of 22 and total synthesis of lycoposerramine W 6. D Selected results from benzylic oxidation screening. E Selected results from N-deletion optimization. a0.02 or 0.05 mmol scale, NH2CO2NH4 (8 eq.), b0.1 mmol scale.

Back to article page