Table 1 Characteristics of participants reporting first and repeat infections (n = 23,591)

From: Prospective cohort study of fatigue before and after SARS-CoV-2 infection in the Netherlands

 

First infections1 (n = 22,705)

Repeat infections2 (n = 6414)

First or repeat infections during bivalent vaccination program3 (n = 7959)

Age at baseline4

 

 18–59 years

10970 (48.3%)

3496 (54.5%)

3438 (43.2%)

 60–85 years

11735 (51.7%)

2918 (45.5%)

4521 (56.8%)

Sex

 

 Female

14652 (64.5%)

4497 (70.1%)

5261 (66.1%)

Medical risk condition5

 

 Yes

6502 (28.6%)

1660 (25.9%)

2434 (30.6%)

Variant of infection6

 

 Delta

1063 (4.7%)

-

-

 Omicron

21642 (95.3%)

6414 (100%)

7959 (100%)

 BA.1/BA.2

11294 (49.7%)

0 (0%)

0 (0%)

 BA.4/BA.5

6119 (27.0%)

294 (4.6%)

2061 (25.9%)

 Post BA.5

4229 (18.6%)

6120 (95.4%)

5898 (74.1%)

Vaccination status prior to the reported infection

 

 Unvaccinated

437 (1.9%)

72 (1.1%)

69 (0.9%)

 Primary series

1961 (8.6%)

205 (3.2%)

187 (2.3%)

 Booster

20307 (89.4%)

6137 (95.7%)

7703 (96.8%)

Acute symptoms

 Symptomatic

21,337 (94.0%)

5597 (87.3%)

7229 (90.8%)

 Asymptomatic

852 (3.8%)

412 (6.4%)

323 (4.1%)

 Missing

516 (2.3%)

405 (6.3%)

407 (5.1%)

  1. 1First infections were reported between 12 July 2021 and 9 March 2024; pre- and post-infection CIS-fatigue questionnaires were completed between 18 May 2021 and 7 April 2024. 2Repeat infections were reported between 13 August 2022 and 15 March 2024; completed pre- and post-infection CIS-fatigue questionnaires were between 27 July 2022 and 7 April 2024. 3First or repeat infections during the bivalent vaccination program were reported between 29 September 2022 and 2 October 2023. 415 participants were excluded because age was missing. 5A medical risk condition was present when a participant reported to have one or more of the following conditions: diabetes mellitus, lung disease or asthma, asplenia, cardiovascular disease, immune deficiency, cancer, liver disease, neurological disease, renal disease, organ or bone marrow transplantation. 6Determined based on the period in which > 90% of the cases in the Netherlands was caused by Delta (12 July 2021–19 December 2021) or Omicron (from 10 January 2022). The Omicron period was subdivided into Omicron BA.1 and BA.2 (10 January 2022–5 June 2022), Omicron BA.5 (6 June 2022–13 November 2022) and post-Omicron BA.5 (from 14 November 2022). In the latter period multiple different Omicron subvariants circulated in the Netherlands.