Fig. 8: Graphical summary of the antimetastatic effect of s-mRNA. | Nature Communications

Fig. 8: Graphical summary of the antimetastatic effect of s-mRNA.

From: Synthetic short mRNA prevents metastasis via innate-adaptive immunity

Fig. 8: Graphical summary of the antimetastatic effect of s-mRNA.The alternative text for this image may have been generated using AI.

Since the chemically synthesized short mRNA (IL1β-mRNA_OMe_AE) is RNase resistant, it can be used to stimulate NK and CTL via the ZC3H12D receptor in vivo. These immune cells enhance its Granzyme B-dependent tumoricidal activity without inducing inflammatory responses that cause severe side effects.

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