Fig. 3: Dysregulation of FOXO1 and PGR at the implantation sites of Grb2d/d mice at GD 4.5. | Nature Communications

Fig. 3: Dysregulation of FOXO1 and PGR at the implantation sites of Grb2d/d mice at GD 4.5.

From: GRB2 regulation of essential signaling pathways in the endometrium is critical for implantation and decidualization

Fig. 3

a Immunohistochemistry analysis of FOXO1 from the uteri of Grb2f/f (i and ii) and Grb2d/d (iii–vi) mice at GD 4.5. b Semi-quantitative analysis of FOXO1 levels in the epithelium of Grb2f/f and Grb2d/d mice at GD 4.5 (n = 5 per group). The results represent the mean ± SEM. ***p < 0.0001, ***p < 0.0001, and **p = 0.0033 by Ordinary one-way ANOVA test. c Immunohistochemistry analysis of PGR from the uteri of Grb2f/f (i and ii) and Grb2d/d (iii–vi) mice at GD 4.5. d Semi-quantitative analysis of PGR levels in the epithelium and stroma of Grb2f/f and Grb2d/d mice at GD 4.5 (n = 5 per group). The results represent the mean ± SEM. ***p < 0.0001, *p = 0.0125, and *p = 0.0163 by Ordinary one-way ANOVA test. Source data are provided in the Source Data file.

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