Fig. 2: Enrichment of DMRs in 15 chromatin states in peripheral blood cells from the NIH Roadmap Epigenomics projects. | Nature Communications

Fig. 2: Enrichment of DMRs in 15 chromatin states in peripheral blood cells from the NIH Roadmap Epigenomics projects.

From: Epigenomic and proteomic analyses provide insights into early-life immune regulation and asthma development in infants

Fig. 2: Enrichment of DMRs in 15 chromatin states in peripheral blood cells from the NIH Roadmap Epigenomics projects.

The 15 chromatin states were consolidated from the NIH Roadmap Epigenomics project based on five histone modification marks (H3K4me3, H3K4me1, H3K36me3, H3K9me3, H3K27me3) in human cells. Chromatin states are 1_TssA (Active TSS), 2_TssAFlnk (Flanking Active TSS), 3_TxFlnk (Transcr. at gene 5’ and 3’), 4_Tx (Strong transcription), 5_TxWk (Weak transcription), 6_EnhG (Genic enhancers), 7_Enh (Enhancers), 8_ZNF/Rpts (ZNF gene & repeats), 9_Het (Heterochromatin), 10_TssBiv (Bivalent/Poised TSS), 11_BivFlnk (Flanking Bivalent TSS/Enh), 12_EnhBiv (Bivalent Enhancer), 13_ReprPC (Repressed PolyComb), 14_ReprPCWk (Weak Repressed PolyComb), 15_Quies (Quiescent/Low). The enrichment p-value was obtained based on two-sided binomial test in 1000 permuted samples. To address multiple testing, we employed a Bonferroni-corrected significant threshold of p = 2.22 × 10−4 (the horizontal dashed line).

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