Fig. 3: Association between DNAm at DMRs and circulating levels of proteins (FDR < 0.0005) among infants hospitalized for bronchiolitis (n = 112). | Nature Communications

Fig. 3: Association between DNAm at DMRs and circulating levels of proteins (FDR < 0.0005) among infants hospitalized for bronchiolitis (n = 112).

From: Epigenomic and proteomic analyses provide insights into early-life immune regulation and asthma development in infants

Fig. 3

Rectangular nodes are DMRs, with the color shade corresponding to number of proteins the DMRs associated with. Oval nodes are proteins, with the color shade corresponding to number of DMRs the protein associated with. Edges represent associations between DMRs and proteins with a Benjamini-Hochberg FDR below 0.0005 after adjusting for covariates. The thickness of the edges corresponds to the statistical significance of the association (obtained from linear regression, two-sided test) calculated as average -log10(P) of the DNAm-protein correlation across all CpG sites within a DMR. Red edges show positive association. Blue edges show negative association.

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