Fig. 3: Effects of meal timing intervention on cardiac vagal modulation and circulating prothrombotic PAI-1 concentration following simulated night work.
The meal timing intervention significantly modified the impact of simulated night work on pNN50 (A, B), RMSSD (C, D), LF/HF (E, F) and PAI-1 (G, H) levels. For all results, cosinor mixed-model analyses were used, and the interaction of meal timing group vs. pre/post simulated night work is reported in the figures. Cosine curves make use of precise circadian phase of each measurement for each participant. Circles indicate data grouped into 15°-circadian windows (~1-hour resolution, except for PAI-1 that is presented with 2-h resolution) with SEM error bars and the top x axes were scaled to the approximate group-averaged clock time of the circadian CBT minimum (reflected by 0o) for reference (i.e., relative clock time). Data correspond to the average (mean ± SEM) across participants per pre/post simulated night work condition and per meal timing group (n = 10 in the NMC group and n = 9 in the DMI group).
