Fig. 4: Differential gene expression and classifier predictions for placental-associated HDP. | Nature Communications

Fig. 4: Differential gene expression and classifier predictions for placental-associated HDP.

From: Molecular subtyping of hypertensive disorders of pregnancy

Fig. 4: Differential gene expression and classifier predictions for placental-associated HDP.The alternative text for this image may have been generated using AI.

Quantile-quantile (QQ) plot of ranked Mann–Whitney U p-values and colored by absolute Cohen’s d effect size for a placental-associated HDP versus all others (genomic inflation factor λ = 2.2), and b placental-associated HDP versus all others with no high risk factors (λ = 5.4). Statistical comparisons in QQ plots are calculated using a two-sided Mann–Whitney U test with multiple test correction by Benjamini–Hochberg. c Effect size for classifier genes in a population with no high risk factors, split into clinical categories based on diagnosis time <37wks, delivery time <37wks, and/or presentation of severe features. 11 samples were missing sufficient information to include in subgroups and were thus excluded from this plot. d Classifier prediction across placental-associated HDP by gestational age at delivery in individuals with no high risk factors. HDP Hypertensive disorders of pregnancy.

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