Fig. 1: Overview of planar-chiral cyclophanes.
From: Enantio-, atrop-, and diastereoselective macrolactonization to access type III cyclophanes
A Approaches to stabilize the conformation of planar-chiral cyclophanes. B Selected example of natural products and drugs containing a type III planar-chiral cyclophane skeleton. C Enantio- and atroposelective macrolactonization for the synthesis of planar-chiral cyclophanes. D Dual catalysis process to form cyclophanes bearing a chiral ansa chain. E Design of a dual catalysis protocol for enantio-, atrop-, and diastereoselective macrocyclization. CALB = Candida antarctical lipase B.
