Fig. 5: Structural properties of the Pd(II) complex and synthetic applications of the derived ligands and organocatalyst.
From: Bis-indole chiral architectures for asymmetric catalysis
A Comparing structural properties of Pd(II) complexes. B X-ray of Pd(II) complex 13. C Rhodium/7a catalyzed asymmetric hydroboration/cyclization. Condition: 18 (1.0 eq), HBpin (1.5 eq), Rh(cod)2BF4 (1.0 mol%), SIDP 7a (1.2 mol%), DCM, 0 °C, 24 h. (D) Rhodium/7b catalyzed asymmetric hydrogenation. Condition: 20 (1.0 eq), Rh(cod)2SbF6 (1.0 mol%), SIDP 7b (1.2 mol%), H2 balloon, DCM, rt, 6 h. E Palladium/7b catalyzed asymmetric allylic alkylation. Condition: rac-22 (1.0 eq), Dimethyl Malonate (2.0 eq), [Pd(allyl)Cl]2 (2.5 mol%), SIDP 7b (6 mol%), ZnEt2 (2.0 eq), THF, 0 oC, 24 h. (F) Secondary amine 11a catalyzed asymmetric Michael addition reaction. Condition: (1) 24 (1.0 eq), 25 (2.0 eq), 11a (5 mol%), TFA (10 mol%), DCM/IPA, 0 oC, 48 h; (2) NaBH4, MeOH, rt, 10 min.
