Fig. 2: RNA-seq analysis of osteoblasts vs. fibroblasts on the RGD-modified surface.
From: Promoting implant osseointegration via the osteoblast-selective β-amino acid polymer strategy
a Venn diagram of four key gene ontology (GO) terms (cytoplasm, cytosol, cytoskeleton, and nucleus) from cellular components categories. b Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the cytoskeleton in GO cellular components categories. The top 15 pathways were shown. The y-axis label represents the KEGG pathway, and the x-axis represents the rich ratio. The size of the dots represents the number of gene enrichment. c–g The level of gene expression by osteoblasts and fibroblasts with respect to: Cdc42 to Arp2/3 pathway (c), Rac to Arp2/3 pathway (d), ROCK downstream pathways toward the activation of myosin II (e), Integrin downstream pathways (f), and focal adhesion (g). Genes expressed to a higher level in osteoblasts and in fibroblasts are blue and red, respectively. h Working model for osteoblast and fibroblast adhesion on the RGD-modified surface.
