Fig. 7: In vivo evaluation of osteoblast-selective MM50CH50 to promote osseointegration.
From: Promoting implant osseointegration via the osteoblast-selective β-amino acid polymer strategy
a Schematic representation and experimental protocol of the rat oral Ti-implant model: maxillary after the incision, flap elevation, creation of the defect (I), and implantation of Ti-screw in the defect region (II and III). b Histological morphologies of methylene blue/acid fuchsin staining showing the bone (red) forming around the Ti implants (black) in five groups after 8 weeks of implantation. c Quantitative analysis of histomorphometrical analyses of BIC%. d Micro-CT images of RGD, KRSR, DM50CO50, or MM50CH50-modified Ti-screw and the uncoated Ti-screw, respectively. e–i Quantitative analysis of bone volume/tissue volume (BV/TV, %) (e), trabecular thickness (Tb.Th, mm) (f), trabecular number (Tb.N) (g), bone surface/bone volume (BS/BV) (h), and trabecular separation (Tb.Sp) (i). Data were mean ± SD of biological replicates (n = 6 rats per group for micro-CT and four rats were randomly selected for histological morphology analysis); Statistical analysis: one-way ANOVA with Tukey post-test.
