Fig. 1: Coarse-grained representation and residue composition of the human TF IDRs studied and POL II C-terminal IDR. | Nature Communications

Fig. 1: Coarse-grained representation and residue composition of the human TF IDRs studied and POL II C-terminal IDR.

From: Selective phase separation of transcription factors is driven by orthogonal molecular grammar

Fig. 1: Coarse-grained representation and residue composition of the human TF IDRs studied and POL II C-terminal IDR.

a FUS (residues 2–214), b TAF15 (residue 2–205), c SP1 (residues 2–507), d SP2 (residues 1-524), e EWS (residues 47–266), f HNF1A (residues 280–631), g POL II (residues 1546–1790). Residues are categorised into 5 groups: cations (R, K)- red, anions (D, E)- blue, aromatic (F, Y, W)- green, aliphatic (A, C, I, L, M, P, V)- black, hydropillic (G, N, S, H, Q, T)- white. The hydrophillic residues in the 1 bead-per-residue molecular representation are coloured differently to distinguish the proteins studied in this work: FUS (yellow), TAF15 (green), SP1 (purple), SP2 (light purple), EWS (orange), HNF1A (red), POL II (blue).

Back to article page