Fig. 7: Summary of condensate interactions.
From: Selective phase separation of transcription factors is driven by orthogonal molecular grammar
a Amino acid sticker types and interactions (as published in84 Fig. 6a, used under CC BY 4.0 license [http://creativecommons.org/licenses/by/4.0]). The favourable interactions (black) promote condensate formation, whereas unfavourable interactions (red) oppose condensate formation. Sticker interactions fall into two orthogonal molecular interactions: 1) Hydrophobic interactions (aliphatic, aromatic and aliphatic-aromatic contacts), and 2) Cationic interactions (cation-π and electrostatic). b–e Different condensate morphologies for the four cases of relative homotypic and heterotypic interaction strengths, illustrated with example (50%-50%) mixtures from simulations undertaken in this work. Corresponding radial density profiles can be found in Supplementary Figs. 28 and 31.
