Fig. 9: RNA polymerase II (POL II) C terminal domain PS with TFs.
From: Selective phase separation of transcription factors is driven by orthogonal molecular grammar
Simulations of 60 POL II molecules (centre) and 30 POL II with: 60 FUS (top left), 60 TAF15 (centre left), 60 EWS (bottom left), 30 SP1 (top right), 30 SP2 (centre right), and 45 HNF1A (bottom right). All simulations were run with a total amino acid concentration of 80,000 μM. The end frame of 3 μs of simulation is displayed as a representative state. POL II molecules are coloured in blue, FUS molecules are coloured in yellow, EWS molecules are coloured in orange, SP1 molecules are coloured in purple, SP2 molecules are coloured in light purple, HNF1A molecules are coloured in red, and TAF15 molecules are coloured in green. Droplets are formed in all simulations of these molecules under these concentration conditions, irrespective of composition. See radial density profiles in Supplementary Figs. 30 and 32).
