Fig. 1: Schematic representation of UvrA structure and NER overall pathway. | Nature Communications

Fig. 1: Schematic representation of UvrA structure and NER overall pathway.

From: Mechanistic understanding of UvrA damage detection and lesion hand-off to UvrB in Nucleotide Excision Repair

Fig. 1: Schematic representation of UvrA structure and NER overall pathway.

a Crystal structure of MtUvrA2 (PDB: 3ZQJ) in two orientations. UvrA domains were colored according to the schematic diagram (the terms ATP-I and ATP-II are used to indicate the proximal and distal ATP binding site, respectively. Similarly, SIG-I and SIG-II are indicative of signature domains, while UBD stands for UvrB binding domain and ID for Insertion Domain). b Schematic representation of the different steps of prokaryotic NER: damage search process (lesion is depicted with a red star) performed by either UvrA2 or UvrA-UvrB complex (1); damage identification and consequent recruitment of UvrB molecules (2); pre-incision complex formation and UvrA detachment (3); UvrC recruitment and damaged DNA incision (4); restoration of the native dsDNA, operated by UvrD, DNA Polymerase I and ligase (5 and 6). Created in BioRender. Ferraris, D. (2024) BioRender.com/f96q610.

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