Fig. 2: Comparison of rates of apparent engraftment of donor feature between FMT and placebo groups. | Nature Communications

Fig. 2: Comparison of rates of apparent engraftment of donor feature between FMT and placebo groups.

From: Detecting microbial engraftment after FMT using placebo sequencing and culture enriched metagenomics to sort signals from noise

Fig. 2: Comparison of rates of apparent engraftment of donor feature between FMT and placebo groups.The alternative text for this image may have been generated using AI.

Detection of apparently engrafted ASVs from 16S rRNA gene sequencing (A), species predicted from shotgun metagenomic sequencing (B) and strain markers predicted from shotgun metagenomic sequencing (C). Top panels: Comparison of the number of apparently engrafted features observed in FMT vs. placebo samples. The x-axis shows the number of patients a feature is apparently engrafted present in, and the y-axis shows the number of features observed to be apparently engrafted in exactly that many patients within FMT (green) or placebo (gray) samples. Middle panels: Counting the number of apparently engrafted features that are unique to FMT samples (green), placebo samples (gray), or present in both (orange). The x-axis shows the number of patients a feature is apparently engrafted in, and the y-axis shows the number of features observed apparently engrafted in exactly that many patients. Bottom panels: The number of apparently engrafted features in FMT samples that are present in patients who responded to FMT treatment (Res,blue lines) and did not respond (NoRes, red lines). The differences between the points on the green and gray (left panels) or blue and red (right panels) lines were used to compute test statistics, with two-sided p values calculated using 1999 permutations by comparing the observed test statistic to the null distribution.

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