Fig. 3: High resolution genome-resolved metagenomics reveals apparent microbial genome engraftment following FMT. | Nature Communications

Fig. 3: High resolution genome-resolved metagenomics reveals apparent microbial genome engraftment following FMT.

From: Detecting microbial engraftment after FMT using placebo sequencing and culture enriched metagenomics to sort signals from noise

Fig. 3: High resolution genome-resolved metagenomics reveals apparent microbial genome engraftment following FMT.

A Top Panel: Comparison of apparently engrafted MAGs in patients who received FMT (n = 12) vs. placebo (n = 12) treatment. The x-axis displays number of patients in which a given MAG appears engrafted. A Middle panel: Counts of MAGs engrafted in only FMT (green), only Placebo (gray), and both (orange). A Bottom panel: MAGs engrafted in FMT patients, observed in responders (Res, n = 6, blue) and non-responders (NoRes, n = 6, red). The differences between the points on the green and gray (A, top panel;) or blue and red (A, bottom panel) lines were used to calculate the test statistics for the permutation tests, with two-sided p values calculated using 1999 permutations by comparing the observed test statistic to the null distribution. B All donor MAGs engrafted in at least one patient. Green represents MAGs exclusively engrafted in FMT recipients, gray indicates MAGs spuriously detected as engrafted in the Placebo group, and orange signifies MAGs detected in both FMT and Placebo treatment cohorts. MAGs are ordered on the x axis by which group(s) of patients they were apparently engrafted in (C). The family-taxonomy of donor MAGs engrafted in at least one patient.

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