Fig. 4: Phenome-wide association study of the PTPRB missense variant rs113791087 in FinnGen. | Nature Communications

Fig. 4: Phenome-wide association study of the PTPRB missense variant rs113791087 in FinnGen.

From: Rare genetic variation in PTPRB is associated with central serous chorioretinopathy, varicose veins and glaucoma

Fig. 4: Phenome-wide association study of the PTPRB missense variant rs113791087 in FinnGen.

To identify potential pleiotropic associations of the rs113791087 variant, a phenome-wide association study was conducted including 2,469 phenotypes as outcomes using logistic regression as implemented in Regenie (v2.2.4). All P values are two-sided and were not adjusted for multiple comparisons. Data are shown for all phenotypes that were at least nominally associated (P < 0.05) with rs113791087. The negative common logarithm of each P value is shown on the y-axis. The genome-wide significance threshold (P = 5×10-8) is shown with a dashed line. The direction of association with the risk of each disease is denoted by symbols (arrow up = increased risk, arrow down = decreased risk).

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