Fig. 9: CMOS: An interactive web platform for visualizing embryonic cell morphologies, intercellular contacts, and cell-resolved lineal gene expressions.

A The lineage-specific expression of the transcription factor, ceh-36, over approximately four hours from the four-cell stage. The relationship between gene expression level and color is displayed on the right. B The 3D views of an exemplary embryo at specified developmental stages (t, imaging time) with an overlay of ceh-36 expression (color-coded as in (A)). The embryo is oriented in a dorsal view with the anterior to the left. C The 3D views of different tissues and organs with highlighted expression of corresponding specific cell fate markers (color-coded as in (A)). The embryo is oriented in a ventral view with the anterior to the left. D The comparative views of a cell-cell contact map in an over 200-minute-old embryo (as seen in (B)): a global (left) and a cell-centric perspective (right). Intercellular contacts can be further examined in detail via an interactive table that appears upon clicking on a cell of interest. The thickness of the connecting lines corresponds to the cell-cell contact area. Expression levels for ceh-36 are superimposed on relevant cells, consistent with the visualization in (B). E The visualization of intercellular contacts for the sixth-tenth Notch signaling events (Fig. 6B) through the website. Source data are provided as a Source Data file.